Sepsis in gastrointestinal perforation Intestinal perforation is a common cause of septic shock 7. The treatment of this septic shock is extremely difficult due to the complex structure of the. 1 Generalized peritonitis caused by gastrointestinal perforation. Abdominal sepsis causes a severe physiological compromise that represents a risk in. 2 Characterized by intestinal inflammation that can progress to necrosis and perforation, NEC often confers life-long sequelae in survivors [,]. 3 intervention carried out per diagnosis of gastrointestinal perforation (or diagnosis of acute abdomen, peritonitis, or sepsis registered in. 4 Without prompt treatment, gastrointestinal or bowel perforation can cause: Internal bleeding and significant blood loss. Peritonitis, inflammation of the inner abdominal wall lining. Permanent damage to the GI tract. Sepsis, a life-threatening reaction to an infection. Symptoms and Causes What causes a gastrointestinal perforation?. 5 Gastrointestinal perforation can cause peritonitis and sepsis so emergency care is essential. People with gastrointestinal perforation often require emergency surgery. This will usually. 6 The signs and symptoms of a perforated GI tract come on gradually, getting worse, although they might not be too noticeable at first. They may include: Severe stomach pain; Chills; Fever; Nausea; Vomiting; Diagnosis and treatment. A perforation anywhere in the GI tract is a medical emergency. 7 Intestinal perforation, defined as a loss of continuity of the bowel wall, is a potentially devastating complication that may result from a variety of disease processes. Common causes of perforation include trauma, instrumentation, inflammation, infection, malignancy, ischemia, and obstruction. 8 Intestinal perforation can present acutely or in an indolent manner (eg, abscess or intestinal fistula formation). A confirmatory diagnosis is made primarily using abdominal imaging studies, but on occasion, exploration of the abdomen (open or laparoscopic) may be needed to make a diagnosis. 9 Abdominal infections are usually polymicrobial and result in an intra-abdominal abscess or secondary peritonitis, which may be generalized or localized (phlegmon). The approach to antimicrobial selection and administration for intra-abdominal infections in adults is discussed here. The general and surgical management of these infections are. 10 The clinical features that suggest fungal infection are he- modynamic insufficiency, upper gastrointestinal perforation, female sex, and antibiotic therapy. 11 12